Methotrexate 59-05-2 Antimetabolite Pharmaceutical Intermediate Research Oncology Use
Product Overview
Methotrexate (CAS 59-05-2) is a folic acid antagonist belonging to the antimetabolite class. It is widely used in pharmaceutical research and biochemical studies due to its ability to inhibit dihydrofolate reductase, thereby affecting DNA synthesis and cell proliferation.
It is commonly applied in oncology research, autoimmune mechanism studies, and pharmaceutical formulation development.
Key Characteristics
- Folic acid antagonist structure
- High biological activity
- Strong enzyme inhibition effect
- Stable crystalline compound
- Suitable pharmaceutical intermediate
- High purity research grade
- Well studied mechanism of action
- Consistent chemical performance
Applications
- Oncology research studies
- Anticancer research systems
- Autoimmune disease research
- Pharmaceutical intermediate synthesis
- Cell biology research systems
- Clinical formulation development
- Laboratory biochemical studies
- Enzyme inhibition studies
Product Specifications
| Item |
Specification |
| Product Name |
Methotrexate |
| CAS Number |
59-05-2 |
| Molecular Formula |
C20H22N8O5 |
| Molecular Weight |
454.44 g/mol |
| Appearance |
Yellow to orange crystalline powder |
| Purity |
≥ 98% |
| Melting Point |
195–203°C |
| Solubility |
Slightly soluble in water |
| Assay Method |
HPLC |
| Heavy Metals |
≤ 10 ppm |
| Loss on Drying |
≤ 0.5% |
Physicochemical Properties
Methotrexate is a structural analogue of folic acid that competitively inhibits dihydrofolate reductase. This inhibition disrupts nucleotide synthesis and DNA replication, making it a key compound in biochemical and pharmaceutical research.
Advantages
- Well-characterized mechanism of action
- High research value in oncology
- Stable crystalline structure
- Suitable for laboratory use
- Consistent analytical performance
- Widely referenced in biochemical studies
Storage Conditions
Store in a tightly sealed container in a cool, dry place. Protect from light and moisture to maintain stability and chemical integrity.
Packaging Options
- 1 g / 10 g research vials
- 100 g / 500 g sealed foil bags
- Custom bulk packaging available
Quality Control
Each batch is analyzed by HPLC for purity, moisture content, and impurity profile to ensure consistent quality suitable for research applications.
